Efficient AcrH2 Catalyzed β-Trifluoromethylation of Carbonyl Compounds by Atom Transfer Radical Addition Reactions

摘要

The use of organic catalysis AcrH2 enables the direct β-trifluoromethylation of carbonyl compounds by atom transfer radical addition reactions with broad substrate scopes under mild conditions.This operationally simple and robust protocol successfully converts a variety of β-chloro carbonyl compounds into the corresponding α-chloro-β-fluoroalkylcarbonyl products.A significant advantage of this method is that it does not require the use of a metal catalyst,thereby avoiding metal residue problems in drug synthesis.