Asymmetric Reduction of Aminoketones with Borane and Chiral Oxazaborolidine Catalyst

摘要

A group of α- and β-N, N-dialkyl amino ketones were reduced enantioselectively by 2 moles of borane-tetrahydrofuran in the presence of 10 mol% of thein-situ formed chiral oxazahorolidine, followed by diluted hydrochloric acid. The resulting amino alcohol-borane complexes were treated with hydrogen chloride-glycol-methanol to give the optically active amino alcohol with the ee up to 99%.