Formal Synthesis of ( + )-Altholactone by Stereoselective Epoxidation Using Magnesium Monoperoxyphthalate (MMPP)

摘要

Synthesis of ( + )-altholactone has been achieved starting from L-tartaric acid using ( 2 S , 3 R , 4 R , 5 R )-2-hydroxymethyl-3 , 4-bis(methoxymethoxy)-5-phenyltetrahydrofuran as key intermediate. The key epoxy ring was introduced by monoperoxyphthalate (MMPP) in high stereoselectivity (8.4:1).