Synthesis of Optically Active β - Alkyl- α - methylene- γ - butyrolactones from Enantioselective Biotransformation of Nitriles, an Unusual Inversion of Enantioselectivity

摘要

A new approach to optically active β-alkyl- α-methylene- γ-butyrolactone derivatives was reported from the Rhodococcus sp.AJ270-catalyzed hydrolysis of appropriate nitriles. The inversion of enantioselectivity of the amidase has bern observed when a methyl protection was introduced into the hydroxy group of the parent substrate.