Novel and Convenient Approach to Synthesis of AZT/d4T H-phosphonates

LIN Chang-Xue(林长学); FU Hua(付华); TU Guang-Zhong(涂光忠); ZHAO Yu-Fen(赵玉芬)

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Novel and Convenient Approach to Synthesis of AZT/d4T H-phosphonates

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A convenient, efficient and general method has been developed for synthesis of H-phosphonate mono and diesters of AZT and d4T through one-pot reaction of phosphonic acid with AZT or d4T and different alcohols using pivaloyl chloride as condensing agent under mild conditions.

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《中国化学（英文版）》 |2004年第3期|225-227|共3页
作者
LIN Chang-Xue(林长学); FU Hua(付华); TU Guang-Zhong(涂光忠); ZHAO Yu-Fen(赵玉芬);
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作者单位

Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China;

Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China;

Beijing Institute of Microchemistry, Beijing 100091, China;

Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China;

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原文格式 PDF
正文语种 chi
中图分类化学;
关键词
H-phosphonate, AZT, d4T, phosphonic acid, pivaloyl chloride;

机译：H-膦酸酯;AZT;d4T;膦酸;新戊酰氯;

Novel and Convenient Approach to Synthesis of AZT/d4T H-phosphonates

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