首页> 中文期刊> 《中国化学:英文版 》 >An Efficient Synthetic Method to Nonnatural α-and β-Tryptophan Analogues via Friedel-Crafts Alkylation of Indoles with Nitroacrylates

An Efficient Synthetic Method to Nonnatural α-and β-Tryptophan Analogues via Friedel-Crafts Alkylation of Indoles with Nitroacrylates

         

摘要

The Friedel-Crafts alkylation of indoles with nitroacrylates could provide α- and β-tryptophan nitro-precursors, respectively, in moderate to good yields under Lewis acid catalysis. The diastereoselectivities of the reaction were enhanced by using 2-substituted indoles. The alkylation products could be easily transformed to nonnatural tryptophan derivatives.

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  • 来源
    《中国化学:英文版 》 |2007年第7期|977-985|共9页
  • 作者

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学 ;
  • 关键词

    机译:色氨酸;硝基丙烯酸酯;吲哚;Friedel-Crafts烷基化;
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