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>An Efficient Synthetic Method to Nonnatural α-and β-Tryptophan Analogues via Friedel-Crafts Alkylation of Indoles with Nitroacrylates
An Efficient Synthetic Method to Nonnatural α-and β-Tryptophan Analogues via Friedel-Crafts Alkylation of Indoles with Nitroacrylates
The Friedel-Crafts alkylation of indoles with nitroacrylates could provide α- and β-tryptophan nitro-precursors, respectively, in moderate to good yields under Lewis acid catalysis. The diastereoselectivities of the reaction were enhanced by using 2-substituted indoles. The alkylation products could be easily transformed to nonnatural tryptophan derivatives.
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