Catalytic Hydrogenation ofα,β-Epoxyketones to β-Hydroxy-ketones with Two Sulfinyl Analogues of Coenzyme NADH Models

摘要

An efficient method for the selective hydrogenation of a series of α,β-epoxyketones to β-hydroxyketones using catalytic amount of two sulfinyl analogues of NAD+ model compounds is reported. The lack of any diastereoselectivily for the formation of β-hydroxyketones with optically pure sulfinyl analogue of NAD+ model supports the radical mechanism proposed previously.