Magnetic HP-β-CD Composite Nanoparticle: Synthesis, Characterization and Application as a Carrier of Doxorubicin in vitro

摘要

Hydroxylpropyl-β-eyclodextrin (HP-β-CD) was introduced to the surface of magnetic nanoparticles in the presence of NH·H2O to synthesize magnetic HP-β-CD composite nanoparticles,which were used as a carder in magnetic targeted drug delivery.The composite nanoparticles were characterized by FTIR,ICP-AES,TEM and VSM.The results showed that the iron content in the composite nanoparticles was 55.4%.The range of size is 10--20 nm and the magnetization is 59.9 emu/g.The capacity of composite nanoparticles for doxorubicin adsorption is 87.8 μg/mg after incubation for 72 h.The cumulative percentage of released doxorubicin in PBS buffer (pH=7.4)in 1,4,10 d were 35.5%,49.3% and 76.5%,respectively.Thus,the magnetic HP-β-CD composite nanoparticles could be a potential carrier in the magnetic targeted drug delivery.