Synthesis and Preliminary Anti-leukemia Activity of N-(Substituted Benzyl)-4-hydroxy-4-substituted Piperidine Derivatives

摘要

In order to find some lead compounds with high inhibition against leukemia, twelve unreported compounds 6a-61 have been synthesized with substituted benzylamines as raw materials via a series of Michael addition, Dieckmann condensation, hydrolysis decarboxylation and reactions with Grignard reagent. Complete assignments have been achieved for the title compounds by 1H NMR, IR, MS and elemental analysis. The preliminary anti-tumor activity tests indicate that the title compounds have good effect on the cellular growth inhibition against K562 cells and have potential anti-leukemia bioactivity.