Stereocontrolled Synthesis of (E)-β, γ-Unsaturated Esters via Palladium-Catalyzed Cross-Coupling of (E)-Alkenylboronic Acids with a-Bromoacetic Esters

摘要

The cross-coupling reaction of trans-alkenylboronic acids with α-bromoacetic esters was firstly studied. It was found that using Pd(OAc)2 as catalyst, a bulky electron-rich phospine, (2-dicyclohexylphospino-biphenyl) as ligand, the reaction can be readily accomplished to give specific (E)-β,γ-unsaturated esters in high yields.