Facile Preparation of Water-Soluble and Cytocompatible Small-Sized Chitosan-Polydopamine Nanoparticles

摘要

In this paper,a kind of novel water-soluble chitosan-polydopamine (CHT-PDA) nanoparticles with a hydrodynamic diameter (Dh) around 10 nm were reported by the combination of self-polymerization of PDA and electrostatic complexation between PDA and CHT in water/DMSO (W/D) mixture at the molar fraction of DMSO (xDMSO =0.37).The preparation method was efficient with a yield of 98％ around.The as-prepared water-soluble CHT-PDA nanoparticles exhibited effective UV-screen ability,enhanced visible-light transmittance and good cytocompatibility via MTT assay,which might be used in transparent formulation for UV protection usage,especially in biological field including sun care application.