Visible Light Accelerated Vinyl C-H Arylation in Pd-Catalysis: Application in the Synthesis of ortho Tetra-substituted Vinylarene Atropisomers

摘要

A visible light accelerated C-H functionalization reaction in palladium-catalyzed arylation of vinyl arenes with diaryliodonium salts is reported in the absence of additional photosensitizer.The kinetic isotope effect (kH/kD) was changed from 3.6 (under darkness) to 1.1 when irradiated by visible light,which indicated that the C-H functionalization step was the rate determining step under darkness and significantly accelerated by the irradiation of visible light.Finally the synthesis of ortho tetra-substituted vinylarene atropisomers with high enantiospecificity was realized via this protocol.