Department of Bioscience & Biotechnology,Dalian University of Technology,Dalian 116024,China;
Department of Bioscience & Biotechnology,Dalian University of Technology,Dalian 116024,China;
Department of Bioscience & Biotechnology,Dalian University of Technology,Dalian 116024,China;
Department of Bioscience & Biotechnology,Dalian University of Technology,Dalian 116024,China;
r-hirudin,histidine residues,SC-mPEG,mono-PEGylation,pH,anticoagulant activity;