Fe3O4Nanoparticles as an Efficient and Magnetically Recoverable Catalyst for the Synthesis of3,4-Dihydropyrimidin-2(1H)-ones under Solvent-Free Conditions

摘要

The catalytic activity of Fe3O4 nanoparticles (NPs) in a one-pot three component condensation reaction consisting of an aromatic aldehyde,urea or thiourea,and a β-dicarbonyl under solvent-free conditions was investigated.This reaction affords the corresponding dihydropyrimidinones (thiones) in high to excellent yields.Compared with the classical Biginelli reactions this method consistently gives a high yield,easy magnetic separation,a short reaction time,and catalyst reusability.