Protection of Hydroxyl Groups as a Trimethylsilyl Ether by1,1,1,3,3,3-Hexamethyldisilazane Promoted by Aspartic Acid as an Efficient Organocatalyst

摘要

A wide variety of alcohols and phenols were protected as trimethylsilyl ethers using 1,1,1,3,3,3-hexamethyl disilazane catalyzed by aspartic acid as a non-toxic, metal-free, and green organocatalyst at room temperature in acetonitrile under mild and heterogeneous conditions. The procedure is operationally simple and the silylated product was obtained in high yield and purity.