冠脉介入治疗术后血脂联素和血红素加氧酶1水平的变化

摘要

Objective:To observe changes of adiponectin (ADPN)and heme oxygenase 1 (HO-1)levels in patients with coronary heart disease (CHD)after percutaneous coronary intervention (PCI),and correlation among ADPN ,HO-1 and oxidized low density lipoprotein (ox-LDL).Methods:A total of 60 CHD inpatients,who received PCI in our department, were regarded as CHD group,another 56 healthy subjects undergoing physical examination were regarded as healthy control group.Levels of ADPN,HO-1 and ox-LDL were measured and compared between two groups before PCI,and between before and eight weeks after PCI in CHD group.Correlation among ADPN,HO-1 and ox-LDL levels were analyzed in CHD patients.Results:Compared with healthy control group,there were significant reductions in levels of ADPN [(18.41 ±5.74)mg/L vs.(5.62±2.16)mg/L]and HO-1 [(38.71±6.95)μg/L vs.(23.87±5.28μg/L)],and significant rise in ox-LDL level [(12.56±5.94)μg/L vs.(31.25±3.95)μg/L]in CHD group before PCI,P =0.001 all.Compared with before PCI,there were significant rise in levels of ADPN [(8.49±1.95)mg/L]and HO-1 [(35.29±2.28)μg/L], and significant reduction in ox-LDL level [(16.74±2.71)μg/L]in CHD group on eight weeks after PCI,P =0.001 all. ADPN and HO-1 levels were significantly negatively correlated with ox-LDL level in CHD patients both before and after treatment (r =-0.648~-0.325,P <0.05 all).Conclusion:PCI can improve coronary blood supply,then increase levels of protectors—adiponectin and heme oxygenase 1 in CHD patients.%目的:观察冠心病(CHD)患者冠状动脉介入治疗(PCI)术后血脂联素(ADPN)和血红素加氧酶1(HO-1)水平的变化及其与氧化型低密度脂蛋白(ox-LDL)水平的相关性.方法:选择我院心内科行PCI的住院CHD患者60例作为CHD组,另选择健康体检的56例健康体检者作为健康对照组.比较两组术前,CHD组术前、术后8周ADPN、HO-1和ox-LDL水平变化,并分析CHD患者ADPN、HO-1与ox-LDL水平的相关性.结果:与健康对照组比较,冠心病组术前ADPN[(18.41±5.74)mg/L比(5.62±2.16)mg/L]和HO-1[(38.71±6.95)μg/L比(23.87±5.28μg/L)]水平明显降低,ox-LDL[(12.56±5.94)μg/L比(31.25±3.95)μg/L]水平明显升高,P均=0.001.与术前比较,术后8周CHD组ADPN[(8.49±1.95)mg/L]和HO-1[(35.29±2.28)μg/L]水平明显升高,ox-LDL[(16.74±2.71)μg/L]水平明显降低(P均=0.001).术前、术后CHD患者ADPN和HO-1水平均与ox-LDL均呈显著负相关(r=-0.648~-0.325,P均<0.05).结论:通过冠状动脉介入治疗可改善冠心病的冠脉血供,从而升高患者保护性因子脂联素和血红素加氧酶1水平.