心房颤动患者高迁移率族蛋白1血清水平

摘要

目的 探讨心房颤动(AF)患者血清高迁移率族蛋白1(HMGB1)水平是否升高.方法 入选的55例阵发性AF患者,33例持续性AF患者,选择36例年龄和性别匹配的无AF体检者作为对照组,采用EUSA法检测血清HMGB1和高敏c反应蛋白(hs-CRP)水平.结果 持续性AF患者血清HMGB1水平较对照组和阵发性AF患者显著增高(8.62±2.18 ng/ml vs 2.22±0.63 ng/ml,5.29±1.43 ng/ml,P均<0,05).阵发性AF患者血清HMGB1水平较对照组高(P<0.05).AF患者血清HMGB1水平与hs-CRP水平呈显著正相关(n=88,r=0.629,P<0.05).结论 AF患者血清HMGB1水平显著上升.%Objective To investigated that whether the serum high mobility group box 1 protein ( HMGB1 ) level is increased in atrial fibrillation (AF) patients. Methods A total of 88 consecutive AF patients were enrolled in this study.Thirty age- and sex-matched people without AF were considered as control group. Serum HMGB1 and high-sensitivity C-reactive protein(hs-CRP) concentration in AF patients and healthy people was measured by ELISA. Results HMGB1 level in persistent AF group (8.62 ±2.18 ns/ml) was higher than that in control group (2.22 ±0.63 ng/ml) and paroxysmal AF group (5.29 ±1.43 ng/ml) (both P＜0.05). HMGB1 level in paroxysmal AF group was higher than that in control group (P ＜0.05 ). There was significantly positive correlation between HMGB1 and hs-CRP in AF patients (n = 88, r =0.629, P ＜ 0.05 ). Conclusion Serum HMGB1 level is markedly increased in AF patients.