Polymorphisms of XPC Gene And Susceptibility of Esophageal Cancer

摘要

Objective:To explore the relationships of the polymorphisms of xeroderma pigmentosum C (XPC) and the susceptibility of esophageal cancer (EC) in Changzhi area,China. Methods:The study was conducted by a case-control study which included 196 cases of EC and 201 cases of controls. XPC PAT polymorphisms were determined with polymerase chain-restriction on fragment length polymorphism (PCR-RFLP). Results:The frequencies of wild homozygote (PAT-/-),mutation heterozygote (PAT-/+) and mutation homozygote (PAT+/+) of XPC were 36.73%,51.53% and 11.74% in case group,37.81%,52.24% and 9.95% in control group,respectively,and there was no significant difference between the two groups (χ2 =0.332,P=0.847). There was no interaction between XPC PAT mutation genotype and xeroderma pigmentosum A (XPA) (S=0.85) and pickled food (S=0.81). Conclusion:A genetic polymorphism in XPC may be not associated with esophageal cancer in Changzhi population.