DETERMINATION OF SERUM HARRINGTONINE IN PATIENTS WITH ANLL AND ITS CLINICAL IMPLICATION

摘要

Harringtonine(H) level in serum was quantified by high-performance liquid chromatographic (HPLC) technique and its pharmacokinetic parameters were determined in 11 patients with ANLL after 4 hours continuous infusion of 4 mg of H. 74 serum samples over the range of H administered 1-6 mg/d were also determined, the dose of H administered paralleled the mean serum H concentration, but the highest concentration were 1.6-7 folds higher than the lowest under the same doses. It seems that the dosage of harringtonine must be individualized in order to achieve better antileukemia effect. It was found that under the similar serum H concentration the marrow blast decrease index (MBDI) in types M4 and M5 of ANLL is much more greater than in M2 after the first course of chemotherapy and in 3 patients of M2, the serum H level and the MBDI show positive correlation.