Objective: To investigate the apoptotic threshold ofadriamycin (ADM) and cisplatin (CDDP) onhepatocellular carcinoma (HCC). Methods: Sensitivitiesof ADM and CDDP on HCC were studied by primarycell culture. Results: The apoptotic threshold of ADMand CDDP were 1.0 μg/ml and 1.5μg/ml respectively (itsclinical dosage was 20 mg and 30 mg respectively).Conclusion: Understanding apoptotic threshold ofanticancer drugs may reduce clinical dosages ofanticancer drugs and reduce the incidence of multidrugresistance (MDR).
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