Proteomics in Discovery of Hepatocellular Carcinoma Biomarkers

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Proteomics in Discovery of Hepatocellular Carcinoma Biomarkers

机译：蛋白质组学在肝细胞癌生物标志物的发现中

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Objective: To discover new proteomic biomarkers of hepatocellular carcinoma. Methods: Surface enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry was used to discover biomarkers for differentiating hepatocellular carcinoma and chronic liver disease. A population of 50 patients with hepatocellular carcinoma and 33 patients with chronic liver disease was studied. Results: Twelve proteomic biomarkers of hepatocellular carcinoma were detected in this study. Three proteomic biomarkers were highly expressed in hepatocellular carcinoma and nine proteomic biomarkers were highly expressed in chronic liver disease. The most valuable proteomic biomarker with m/z=11498 had no similar diagnostic value as α-fetoprotein. Conclusion:Some of the twelve proteomic biomarkers may become new biomarkers of hepatocellular carcinoma.

机译：目的：发现肝细胞癌的新的蛋白质组学生物标志物。方法：采用表面增强激光解吸/电离飞行时间质谱（SELDI-TOF）来发现可区分肝细胞癌和慢性肝病的生物标志物。研究了50例肝细胞癌患者和33例慢性肝病患者。结果：本研究检测到十二种肝细胞癌蛋白质组学生物标志物。三种蛋白质组生物标志物在肝细胞癌中高表达，九种蛋白质组生物标志物在慢性肝病中高表达。 m / z = 11498的最有价值的蛋白质组学生物标志物没有与甲胎蛋白相似的诊断价值。结论：十二种蛋白质组生物标志物中的某些可能成为肝细胞癌的新生物标志。

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《中国癌症研究（英文版）》 |2007年第3期|159-164|共6页
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Department of Gastroenterology,the Second Affiliated Hospital,the Second Military Medical University,Shanghai 200043;

The First Out-Patient Clinic,the General Logistics Department of the PLA;

Department of Gastroenterology,the Second Affiliated Hospital,the Second Military Medical University,Shanghai 200043;

Department of Statistics and Finance,China Science & Technology University;

Department of Surgery,Eastern Hepatobiliary Surgery Hospital,the Second Military Medical University,Shanghai 200043;

The Second Military Medical University;

Department of Public Health & Molecular Biology,Shanghai Municipal Center for Disease Control and Prevention;

Department of Public Health & Molecular Biology,Shanghai Municipal Center for Disease Control and Prevention;

Department of Gastroenterology,the Second Affiliated Hospital,the Second Military Medical University,Shanghai 200043;

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收录信息中国科学引文数据库(CSCD);
原文格式 PDF
正文语种 chi
中图分类肝肿瘤;
关键词
Proteomics; Biomarker; Hepatocellular carcinoma;

机译：蛋白质组学;生物标志物肝细胞癌;

Proteomics in Discovery of Hepatocellular Carcinoma Biomarkers

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