A 'Stem Cells in Cancer' special issue in Translational Cancer Research

摘要

Somatic stem cells(SSCs),being essential in maintaining homeostasis of normal tissue,replenish dying cells and regenerate damaged tissues for organism.On the other hand,with the self-renewed ability,SSCs are ideal cellular targets to be acquired in multiple mutations transforming SSCs to cancer stem cells(CSCs)which cause malignancies and even recurrence after cancer treatment if CSCs fail to be eradicated(1).One year after Drs.John B.Gurdon and Shinya Yamanaka shared the 2012 Nobel Prize in Physiology or Medicine for their discovery that mature cells can be reprogrammed to