微生物生产3-羟基丁酮研究进展

摘要

3-Hydroxybutanone, an important chemical intermediate and multifunctional material, was widely used in the industries of food additives, pharmaceuticals, chemicals and so on. Compared with the method of chemical or biocatalysis, the fermentation by industrial microorganisms had advantages of the low cost, high safety, high purity, and high yield. The progress in the breeding of industrial strains, metabolic pathway and its control mechanisms, and fermentation optimization strategies were summarized. Furthermore, the potential of Torulopsis glabrata as 3-hydroxybutanone production strain was suggested.%3-羟基丁酮是一种重要的化学合成中间体和多功能材料,广泛应用于食品、制药、化工等领域.相比化学合成法和生物酶转化法,微生物发酵法具有低成本、高纯度、高产率等特点.本文在详细总结微生物发酵生产3-羟基丁酮在菌种选育、代谢机制以及高产策略等方面研究进展的基础上,展望了微生物发酵法生产3-羟基丁酮的优势和发展方向.