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《中国生物医学工程学报:英文版》
>Observations on Cardiac Output in Animal Experiments and Clinical Application of Jiuling Bileaflet Mechanical Valve Prosthesis
Observations on Cardiac Output in Animal Experiments and Clinical Application of Jiuling Bileaflet Mechanical Valve Prosthesis
Objective:To observe the cardiac output(CO)in animals and patients undergone valve replacement with Jiuling bileaflet mechanical valve prosthesis.Methods: 1.Animal experiments:6 sheep that subjected to mitral replacement with a 21-mm-valve prosthesis were measured by open cardiac catheterization intraoperatively. Echocardiographic and open cardiac catheterization under dobutamine stress were performed on 2 sheep survival for 30 months post-operation.2.Patient measurements:CO of 14 cases of aortic valve and 10 cases of mitral valve was measured by open cardiac catheterization,and after 12 months,it was measured by echocardiography.Results:1. Animal experiments:The mean CO of 6 sheep was 2.5 L/min intraoperatively by catheterization,and that of 2 sheep survival for 30 months post-implant was 3.0 L/min by echocardiography and 2.9 L/min by catheterization,respectively.2.Patient measurements: The mean cardiac index of 4 patients with 21 mm valve replacement was(2.55±0.27) L/min/m2by catheterization,and was(2.84±0.13)L/min/m2 by echocardiography after 12 months.Conclusion:This study demonstrates that cardiac function on animals and patients return to normal activity after undergone the valve replacement,and the newly valve prosthesis shows excellent hemodynamic performance.
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