阿托伐他汀联合抗凝药物在老年激素性股骨头坏死中的应用价值

摘要

Objective To study the application value of atorvastatin combined with anticoagulation drugs in the treatment of steroid-induced necrosis of the femoral head in the elderly.Methods From February 2013 to January 2016, 112 cases elderly patients accepted treatment of steroid-induced necrosis of the femoral head in our hospital were selected.They were divided into observation group and control group with 56 cases in each group randomly.The two groups were treated with anticoagulant therapy, the observation group received atorvastatin on the basis of control group.The efficacy and indicators between two groups after treatment were compared.Results The excellent and good rate was in observation group was 92.86%, which was higher than 66.07% in control group ( P <0.05 ) .The pain degree, walking ability and total joint mobility score of the observation group were significantly higher than those in the control group(P<0.05).After treatment, plasma viscosity and hematocrit of the observation group were significantly lower than the control group(P<0.05).The time of collapse of the femoral head and the index of necrosis of the observation group were significantly lower than the control group(P <0.05).Conclusion Atorvastatin combined with anticoagulant drugs in the treatment of elderly patients with steroid-induced femoral head necrosis has significant effect, could effectively improve the quality of life of patients with good safety, high application value.%目的：研究阿托伐他汀联合抗凝药物在老年激素性股骨头坏死中的应用价值。方法选取从2013年2月～2016年1月，于杭州市萧山区第一人民医院骨科接受治疗激素性股骨头坏死的老年病患112例。根据数字随机法分为观察组及对照组各56例。2组病患均给予抗凝药物治疗，观察组在此基础上加用阿托伐他汀。对比2组治疗后疗效及各项指标。结果观察组优良率为92．86％，明显高于对照组的76．79％（P＜0．05）。观察组疼痛程度、行走能力以及关节总活动度评分均显著高于对照组（P＜0．05）。治疗后观察组血浆黏度和血细胞比容均显著低于对照组（ P＜0．05）。观察组股骨头坍塌时间和坏死指数均显著低于对照组（ P＜0．05）。结论阿托伐他汀联合抗凝药物治疗老年激素性股骨头坏死效果显著，能有效改善病患的生活质量，安全性好，应用价值高。