胃肠安颗粒对结直肠癌患者术后康复进程的影响

摘要

Objective To investigate the effect of Weichang'an granule on the healing process of colorectal patients. Methods 67 cases of laparoscopic treatment of colorectal cancer patients from April 2013 to February 2017 as the research object, were randomly divided into control group (n=33) and observation group (n=34) after surgery, both groups were treated with FOLFOX4 chemotherapy. The control group received chemotherapy with Kang ai needle therapy, the observation group using Weichang'an granule, 3 weeks for a cycle, a total of 6 treatment cycles. After the end of treatment were compared between the TCM syndrome score, serum tumor markers carcinoembryonic antigen (CEA), tumor associated carbohydrate antigen (CA242), Carbohydrate antigen 125 (CA125) expression level, according to the SF-36 quality of life scale for the assessment of quality of life before and after intervention. Results After treatment, the CEA, CA242, CA125 of control group were (14.8+2.3) g/L, (15.7+2.1) U/mL, (28.7+3.8) U/mL, the observation group were (10.3+1.6) g/L, (12.4+1.7) U/mL, (22.6+2.9) U/mL, all significantly lower than before treatment, and the observation group of each marker was lower than that of control group (P<0.05). Conclusion Weichang'an granule can significantly enhance the immune ability, improve the clinical symptoms of patients with spleen deficiency, and inhibit the production of serum tumor factors, promote the postoperative recovery.%目的 探讨胃肠安颗粒对结直肠患者术后康复进程的影响.方法 选取东阳市中医院选择2013年4月~2017年2月收治的67例腹腔镜治疗结直肠癌患者,采用随机数字表分为对照组(n=33)与观察组(n=34),术后2组均予以FOLFOX4基础化疗,对照组在化疗基础上采用康艾针治疗,观察组使用胃肠安颗粒,3 w为一个周期,共治疗6个周期.疗程结束后比较2组中医证候积分,检测治疗前后血清肿瘤标志物癌胚抗原(CEA)、癌相关糖抗原(CA242)、糖类抗原125(CA125)表达水平,根据SF-36生活质量量表评估干预前后生活质量.结果 治疗后对照组CEA、CA242、CA125依次是(14.8±2.3)μg/L、(15.7±2.1)U/mL、(28.7±3.8)U/mL,观察组(10.3±1.6)μg/L、(12.4±1.7)U/mL、(22.6±2.9)U/mL,均显著低于治疗前,且观察组各标志物低于对照组,差异有统计学意义(P<0.05).结论 胃肠安颗粒可显著增强机体免疫能力,改善脾虚证患者临床症状,并抑制血清肿瘤因子生成,促进术后康复.