不同剂量阿司匹林对老年心血管疾病患者肾功能的影响

摘要

目的 观察不同剂量阿司匹林对不同年龄段老年心血管疾病患者肾功能的影响.方法 选取2014年1月~ 2016年3 月在浙江省荣军医院住院患者.入选心血管病患者其中尿酸正常者144例,伴高尿酸血症者(包括痛风)144例,共288例.将上述2大组按年龄60~70岁,71~80岁,80岁以上分别分为3个亚组,每亚组为48例;各亚组内随机分组选入不使用阿司匹林(0mg/d)和使用不同剂量阿司匹林(50mg/d,100mg/d,150mg/d)共为4个小组,每小组12例.使用前和使用后6个月和12个月时常规检测血常规、肝肾功能、尿素氮(BUN) 、血肌酐(Scr) 水平和肾小球滤过率(eGFR) (MDRD 公式计算) 以及血、尿β2-微球蛋白.结果 治疗前各小组患者身体质量指数(BMI) 、血压、血红蛋白、血清白蛋白、血小板计数差异均无统计学意义;治疗后第6、12个月,尿酸正常患者和高尿酸患者0mg/d、50mg/d、100mg/d和150mg/d剂量阿司匹林患者在BUN、Scr、eGFR、血β2-微球蛋白、尿β2-微球蛋白差异无统计学意义.结论 不论尿酸高低,不同剂量阿司匹林对各年龄段老年心血管疾病患者肾功能没有明显影响,可安全使用.%Objective Aspirin is a non steroidal anti-inflammatory drugs, whether or not which does harm to renal function in the course of using, there is a big debate at home and abroad.In this paper, The aim of this study was to observe the effects of different doses of aspirin on renal function in elderly patients with cardiovascular disease at different ages.MethodsWe Selected a total of 288 patients with cardiovascular disease from January 2014 to March 2016 in Zhejiang Rongjun hospital.There were 288 cases of cardiovascular disease, including 144 cases of normal uric acid, 144 cases with hyperuricemia (including gout).The two groups according to the age of 60 to 70 years, 71 to 80 years old, over 80 years old respectively into three subgroups, each subgroup of 48 cases;Each subgroup was randomly selected without the use of aspirin (0mg/d) and the use of different doses of aspirin (50mg/d, 100mg/d, 150mg/d) for a total of four groups, each which is 12 patients.We detect patients routine blood tests, liver and kidney function, blood urea nitrogen (BUN), blood creatinine (SCR) levels and glomerular filtration rate (GFR) (MDRD) and blood and urine beta 2-microglobulin used aspirin before and used after 6 months and 12 months.ResultsBefore treatment, there were no significant differences in body mass index (BMI), blood pressure, hemoglobin, serum albumin and platelet count between various groups of the same age group.After treatment for 6 and 12 months,Uric acid normal patients and high uric acid patients with 0mg/d, 50mg/d, 100mg/d or 150mg/d dose of aspirin has no statistical difference in BUN, Scr and eGFR, 2-microglobulin Ccr, blood, urine beta 2-microglobulin.ConclusionRegardless of uric acid, different doses of aspirin had no significant effect on renal function in elderly patients with cardiovascular disease, and can be safely used.