Brain-derived neurotrophic factor promotes pulmonary artery endothelial cells proliferation and inflammatory cytokines secretion

摘要

Pulmonary hypertension(PH)is a progressive disease caused by pathological vascular remodeling of arterial vessels and elevated pulmonary artery pressure that result in pressure overload of the heart right ventricle eventually causing its failure.Pulmonary artery endothelial cells(PAECs)dysfunction and local inflammation play important roles in the development of PH.Recent studies suggested that neurotrophin growth factors,particularly brain-derived neurotrophic factor(BDNF)and its high-affinity receptor TrkB,were significantly increased in the PAECs under the hypoxia condition.The aim of this study was to explore the possible effects of BDNF on PAECs.