miR-200a suppresses glioma cell migration and invasion via directly targeting MAGED4

摘要

Melanoma-associated antigen D4(MAGED4)is overexpressed in glioma and has been associated with WHO grade and survival.Here we investigated the exact function of MAGED4 during glioma progression and its regulatory mechanism.Cell migration and invasion were evaluated following up-and down-regulation of MAGED4 expression in glioma cell lines U87MG,U251,A172 and SHG44.Furthermore,we combined bioinformatics tools with biological validation assays to determine the miRNA targeting MAGED4.