GABAergic interneurons mediate inhibitory signal from A-fiber to nocicetive C-fiber

摘要

We investigate the morphological and electrophysiological mechanism of gate control for pain.We proposed that the regulation of peripheral A-fibers on C fibers was mediated by the GABAergic interneurons in the spinal cord.The cobra venom was injected to the sciatic nerve to establish a neuropathic pain model due to peripheral demyelination within A-fiber.The content of r aminobutyric acid(GABA)in spinal cord and cerebrospinal fluid was asssed by high performance liquid chromatography(HPLC).The microstructure of A-fiber,C-fiber and the GABAergic neurons in the spinal cord was observed by immunofluorescence staining.