SOX2在成年小鼠室周器官细胞的表达及其意义

摘要

Objective:To observe the expression and difference of SOX2 positve cells in the adult mouse circumventicular organs (CVOs) and subventricular zone. Methods: SOX2 positive cells of adult male mice were detected by immunohistochem-ical staining. Results: The SOX2 positive cells were densely found in area postrema (AP) , median eminence (ME), subfor-nical organ (SFO), subcommissural organ (SCO), choroid plexus and subventricular zone. Except SCO, the percentages of postive cells were different between CVOs and subventricular zone. Conclusion : Abundent SOX2 positive cells are found in CVOs of adult mice that suggest the existence of neural stem/progenitor cells, which can proliferate and differentiate into new neurons and/or glia.%目的:检测成年小鼠SOX2在成年小鼠室周器官细胞和脑室下区细胞的表达及其差异.方法:成年BALB/c雄性小鼠,免疫组织化学检测SOX2在室周器官细胞的表达.结果:SOX2在最后区(AP)、正中隆起(ME)、穹隆下器(SFO)、联合下器(SCO)和脉络丛细胞均有强表达,与脑室下区SOX2阳性细胞比较,除SCO外,均有差异.结论:在成年小鼠室周器官分布有大量的SOX2阳性细胞,表明成年小鼠室周器官可能存在具有增殖和分化潜能的神经干细胞/祖细胞.