RUNX3蛋白在不同分化胃癌、直肠癌组织中的表达变化

摘要

目的:观察RUNX3蛋白在不同分化的胃癌、直肠癌组织中的表达情况.方法:应用免疫组织化学SP法、免疫印迹检测104例胃癌、82例直肠癌组织RUNX3蛋白表达.结果:RUNX3蛋白在胃癌、直肠癌组织中的阳性表达率低于其在癌旁相应正常胃、直肠黏膜组织；在低分化胃癌组织中的阳性表达率低于高、中分化胃癌组织.结论:RUNX3蛋白表达降低、缺失与胃癌、直肠癌的发生、分化程度有密切关系.%Objective:To investigate RUNX3 protein expression in different differentiated gastric and rectal carcinoma. Methods: RUNX3 protein expressions were detected by SP immunohistochemical and Western blotting methods in 104 cases gastric carcinoma, and 82 cases rectal carcinoma. Results: The expression of RUNX3 protein in gastric and rectal carcinoma was lower than that in paracancerous normal tissues. And, the expression of RUNX3 in poor differentiated gastric carcinoma was significantly lower than that in well and intermediatly differentiated ones. Conclusion: The expression of RUNX3 pro tein is correlated with the development of gastric and rectal carcinoma