EEG-controlled functional electrical stimulation rehabilitation for chronic stroke:system design and clinical application

摘要

Stroke is one of the most serious diseases that threaten human life and health.It is a major cause of death and disability in the clinic.New strategies for motor rehabilitation after stroke are undergoing exploration.We aimed to develop a novel artificial neural rehabilitation system,which integrates brain--computer interface(BCI)and functional electrical stimulation(FES)technologies,for limb motor function recovery after stroke.We conducted clinical trials(including controlled trials)in 32 patients with chronic stroke.Patients were randomly divided into the BCI-FES group and the neuromuscular electrical stimulation(NMES)group.The changes in outcome measures during intervention were compared between groups,and the trends of ERD values based on EEG were analyzed for BCI-FES group.Results showed that the increase in Fugl Meyer Assessment of the Upper Extremity(FMA-UE)and Kendall Manual Muscle Testing(Kendall MMT)scores of the BCI-FES group was significantly higher than that in the sham group,which indicated the practicality and superiority of the BCI-FES system in clinical practice.The change in the laterality coefficient(LC)values based onμ-ERD(ΔLCm-ERD)had high significant positive correlation with the change in FMA-UE(r=0.6093,P=0.012),which provides theoretical basis for exploring novel objective evaluation methods.