Chemical constituents from endophytic fungus Plectosphaerella cucumerina YCTA2Z1 of Cynanchum auriculatum

摘要

Objective: To study the chemical constituents from the Et OAc extract of endophytic fungal Plectosphaerella cucumerina YCTA2 Z1.Methods: The chemical constituents were isolated and purified by silica gel column,Sephadex LH-20,and reverse-phase C-18 column chromatography as well as crystallization.Results: Thirteen compounds were isolated from the EtOAc extract of the fungal strain YCTA2 Z1.Their chemical structures were elucidated according to the spectral evidence.They were identified as caudatin(1),baishouwubenzophenone(2),cynandione B(3),asterbatanoside A(4),p-hydroxyphenethyl-O-β-D-glycoside(5),caffeic acid(6),ferulic acid(7),2,5-dihydroxyacetophenone(8),protocatechuic acid(9),vanillic acid(10),stearic acid(11),azelaic acid(12),and succinic acid(13).Conclusions: It is the first chemical study on endophytic fungi from Cynanchum auriculatum and all the compounds are obtained from the species,the genus,as well as the family Plectosphaerellaceae for the first time.