Objective To explore the clinical relations between the vascular complication of type 2 diabetes and mild cognitive impairment. Methods 119 patients with type 2 diabetes were divided into three groups according to the vascular complications. Group A was macrovascular complication. Group B was microvascular complication. Group C was complex vascular complication. The three groups were tested pressure, fasting plasma glucose ( FPG ), glycosylated hemoglobin ( HbA1c ), cholesterol ( TC ), triglyceride ( TG ), Trail making test, Wisconsion card sorting test ( WCST ), Wechsler Memory Scale ( WMS ). Results The data of pressure, FPG, HbA1c, TC , and TG in patients were no difference ( P > 0. 05 ). But the test dates of Trail making test, WCST, short -term memory and immediate memory in the three groups were significant difference ( P <0. 05 ). The data of the C group was worst. The B group was worse. About the long - term memory, the test dates of A group was best significantly compared with B group and C group ( P < 0. 05 ). There were no significant difference between B group and C group ( P >0. 05 ). Conclusion The mild cognitive impairment of type 2 diabetes was relative with the vascular complication. But the microvascular complication was more important compared with the macrovascular complication in the role of mild cognitive impairment.%目的 探讨2型糖尿血管并发症与早期认知障碍的相关性.方法 选取119例2型糖尿病患者,根据血管并发症情况分为3组(A组为大血管并发症组,B组为微血管并发症组,C组为联合血管并发症组),均测试血压、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG),并完成连线测验、威斯康星卡片分类测验(WCST)、韦氏记忆量表测验.结果 3组糖尿病患者的血糖、血脂、血压、HbA1c水平间差异无统计学意义(P＞0.5);但3组患者的连线测验、WCST、韦氏记忆量表中的短时记忆及瞬时记忆成绩比较,差异均有统计学意义(P＜0.05),且C组成绩最差,B组成绩次之;长时记忆方面,A组患者成绩显著优于B、C组,差异有统计学意义(P＜0.05),而B组与C组比较差异无统计学意义(P＞0.05).结论 2型糖尿病患者联合血管损伤较单纯血管损伤的认知障碍更加明显;但与单纯血管损伤相比,其微血管并发症较大血管并发症危险性增加.
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