胰岛素泵强化治疗对胃癌合并2型糖尿病患者C反应蛋白的影响

摘要

目的 探讨胰岛素泵强化治疗对胃癌合并糖尿病患者术后C反应蛋白(CRP)的影响.方法 将86例胃癌合并2型糖尿病患者随机分为常规组(A组)46例和胰岛素强化治疗组(B组)40例,于术前和术后第3、7天测量空腹血糖(FBG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、CRP.结果 A组术后第3、7天FBG、FINS、lnHOMA-IR、CRP水平均高于术前,差异有统计学意义(P＜0.05);B组术后第3、7天FBG、FINS、lnHOMA-IR、CRP水平均低于A组,差异均有统计学意义(P＜0.05).CRP与年龄、体质指数、FINS均呈正相关(P＜0.05).结论 胰岛素强化治疗能减轻术后炎症反应,可能与改善胰岛素抵抗有关.%Objective To explore the influence of intensive insulin therapy ( IIT ) on C-reactive protein in gastric cancer patients with complicated type 2 diabetes mellitus. Methods Eighty - six gastric cancer patients with complicated type 2 diabetes mellitus were randomly divided into the control ( group A, 46 cases ) and IIT ( group B, 40 cases ) group. Fasting blood glucose ( FBG ), fasting insulin ( FINS ) and C-reactive protein ( CRP ) were detected before and on 3rd and 7th day after surgery. Insulin resistance index was calculated using homeostasis model assessment ( HOMA ) as well. Results Levels of FBG,FINS and lnHOMA - IR between the IIT and the control group were significantly different postoperatively. Levels of FBG, FINS and lnHOMA -IR in the IIT group were lower than those of the control group ( P＜0.05 ). Body mass index ( BMI ), FINS levels and AGE were highly positively correlated with index of CRP ( P ＜ 0.05 ) . Conclusion Intensive insulin therapy may decrease the postoperative inflammatory reaction, which may be related to the improvement of insulin resistance.