2型糖尿病患者生活质量和抑郁状态与其低血糖反应的关系研究

摘要

Objective To explore the impact of quality of life and depression on hypoglycemia in patients with type 2 diabetes mellitus ( T2DM ) . Methods A total of 458 patients were, according to whether they suffered from hypoglycemia within the past half year, divided into hypoglycemia group and non - hypoglycemia group. The single factor analysis was used ton investigate the differences between the two groups in scores of quality of life, depression, fasting blood sugar ( FBG ), glycosylat-ed hemoglobin ( HbA1c), and body mass index ( BMI ) . Then the significant variables in single factor analysis were taken as the independent variables for multivariate regression analysis to explore the risk factors of hypoglycemia. Results ( 1 ) The BMI in the hypoglycemia group was significantly higher than that in the non - hypoglycemia group [ ( 24. 8 ± 1.9) kg/m2 vs. ( 24. 2 ± 1.8) kg/m2 ] ( P <0. 05 ) . ( 2 ) The total scores of physical health [ ( 301. 3 ±30. 3 ) vs. ( 312. 8 ±31. 2 )] and psychological health [ ( 304. 0 ±30. 8 ) vs. ( 316. 1 ±31. 4 ) ] were significantly lower in the hypoglycemia group than the non -hypoglycemia group ( P <0. 01 ) . The score of Depression Score of Patient Health Questionnaire ( PHQ -9 ) was significantly higher in the hypoglycemia group than in the non - hypoglycemia group ( P < 0. 05 ). (3) The multivariate regression analysis revealed that the total scores of physical health [ OR = 0. 911 , 95% CI ( 0. 896, 0. 958 ), P = 0. 032 ] psychological health [ OR = 0. 835 , 95% CI(0.711, 0.926), P =0. 008 ] and PHQ -9 ( OR = 1. 318 , 95% CI ( 1. 115, 1.481), P = 0. 022 ] were associated with hypoglycemia. Conclusion The quality of life and depression are associated with hypoglycemia in patients with T2DM.%目的 探讨2型糖尿病(T2DM)患者生活质量和抑郁状态与其低血糖反应的关系.方法 根据既往半年内是否发生低血糖反应分为低血糖组和非低血糖组.首先单因素分析低血糖组和非低血糖组生活质量评分、抑郁状态评分、空腹血糖、糖化血红蛋白和体质指数的差别,然后以单因素分析有统计学意义的变量为自变量进行多元回归分析,探讨低血糖的危险因素.结果 (1)低血糖组体质指数高于非低血糖组[(24.8±1.9)kg/m2 比(24.2±1.8)kg/m2 ],差异有统计学意义(P＜0.05);(2)低血糖组躯体健康总评得分[(301.3±30.3)分 比(312.8±31.2)分]和心理健康总评得分[(304.0±30.8)分 比(316.1±31.4)分]均低于非低血糖组,差异有统计学意义(P＜0.01);低血糖组健康问卷抑郁量表(PHQ-9)评分差于非低血糖组,差异有统计学意义(P＜0.05);(3)多元回归分析显示,躯体健康总评[OR=0.911,95%CI(0.896,0.958),P=0.032]、心理健康总评[OR=0.835,95%CI(0.711,0.926),P=0.008]和PHQ-9评分[OR=1.318,95%CI(1.115,1.481),P=0.022]对低血糖反应发生的影响有统计学意义.结论 生活质量和抑郁状态与低血糖反应有关.