不同引产方式用于终止孕12~15周妊娠的临床研究

摘要

Objective:To investigate the clinical effectiveness of different methods in termination of 12-15 weeks of pregnancy.Method:A total of 170 women seeking for terminating 12-15 weeks of gestation were randomly divided into three groups,group A(n=60,Misoprostol combined with extra-amniotic cavity injection of Rivanol),group B(n=57,Mifepristone combined with vaginal Misoprostol),group C(n=53,extra-amniotic cavity injection of Rivanol).The clinical effectiveness of these three methods was evaluated.Result:Compared with group C,higher success rate of labor induction,lower rate of post-abortion curettage, less amount of vaginal bleeding were found in group A and group B(P<0.05).Compared with group A,lower rate of post-abortion curettage was observed in group B, there were no significant differences in the success rate of labor induction and amount of vaginal bleeding between group A and group B.There were no significant adverse reactions among three groups.Conclusion:Mifepristone combined with vaginal Misoprostol in termination of 12-15 weeks of pregnancy are high success rate,simple,safe,small side effect,and worthy of widely clinical.%目的：探讨不同引产方式用于终止12~15周妊娠的临床效果。方法：将170例停经12~15周孕妇需要终止妊娠者随机分为三组。A组60例，米索前列醇联合利凡诺羊膜腔外引产；B组57例，口服米非司酮及阴道放置米索前列醇药物引产；C组53例，利凡诺羊膜腔外引产。结果：A、B组单次引产成功率明显高于C组，清宫率、产后2 h阴道流血量均低于C组，差异有统计学意义(P<0.05)；A组与B组比较，单次引产成功率、阴道流血量差异无统计学意义(P>0.05)，B组清宫率低于A组，差异有统计学意义(P<0.05)；三组患者均无明显不良反应。结论：米非司酮联合阴道放置米索前列醇用于终止12~15周妊娠引产成功率高，简单、安全、出血少、副作用少，值得临床推广。