肥胖型多囊卵巢综合征患者临床及内分泌代谢特征的研究

摘要

Objective:To investigate the clinical and endocrine and metabolic characteristics of the obese patients with polycystic ovary syndrome.Methods:160 patients with PCOS were divided into the obese group with 60 cases and non obese group with 100 cases,at the same time,we selected 100 patients who were treated for the tubal factor about the regular menstruation,basal body temperature duplex infertility as the control group,and they were divided into the simple obesity group with 25 cases and the normal control group with 75 cases.All patients were given the height,weight,waist circumference and body measurement,at the same time,they were also given the color doppler examination and the reproductive endocrine examination and so on.Results:The weight,body mass index,waist circumference,waist hip ratio of the obesity observation group were significantly higher than those of the non obese observation group(P<0.05);the weight,body mass index,waist circumference,waist hip ratio,hirsutism score of the simple obesity group were significantly higher than those of the normal control group(P<0.05);all of the observation group acne grading were significantly higher than those of all the control group scores(P<0.05);the SHBG of the obesity observed group and simple obesity control group were significantly lower than that of the non obese observation group and normal control group(P<0.05);the comparison of free testosterone and estradiol between the obesity observation group,non obesity observation group and the simple obesity control group,normal control group had statistically significant(P<0.05).Conclusion:The endocrine and metabolic disorder of the obese PCOS patients is more serious than non obese type patients.%目的:探讨肥胖型多囊卵巢综合征患者(PCOS)临床及内分泌代谢特征.方法:收治PCOS患者160例,分为肥胖组60例和非肥胖组100例;同时收集因输卵管因素就诊的月经规律、基础体温双相不孕患者100例作为对照,分为单纯肥胖组25例和正常对照组75例.所有患者均进行身高、体重、腰围等测量,同时进行彩色多普勒超声检查、生殖内分泌检查等.结果:肥胖观察组体重、体重指数、腰围、腰臀比与非肥胖观察组比较明显偏高(P<0.05);单纯肥胖对照组体重、体重指数、腰围、腰臀比、多毛评分与正常对照组比较明显偏高(P<0.05);所有观察组的痤疮评分均明显高于所有对照组的评分(P<0.05);肥胖观察组和单纯肥胖对照组SHBG均明显低于非肥胖观察组和正常对照组(P<0.05);肥胖观察组和非肥胖观察组游离睾酮和雌二醇与单纯肥胖对照组和正常对照组比较差异有统计学意义(P<0.05).结论:肥胖型PCOS患者较非肥胖型存在更严重的内分泌及代谢紊乱.