磁敏感加权成像评估阿尔茨海默病脑内铁沉积的临床意义

摘要

Objective:To observe the difference of brain iron contents between patients with alzheimer disease(AD) and normal control group by SWI technology,to explore the correlation between the phase value and the MMSE score.Methods:31 patients with AD(the AD group) and 10 healthy elderly people(the NC group) were given hippocampus and caudate nucleus SWI scan.The correlation between the various brain regions phase values of AD group and the MMSE score were compared.Results:The left and right sides of hippocampus and caudate nucleus in the AD group had different degrees of iron deposition.AD group were significantly higher than the control group(P<0.05).The left and right hippocampus angle values had correlation with MMSE score,and the correlation coefficents were respectively 0.43 and 0.45(P<0.05).Conclusion:The phase value can be used as a sensitive and effective method to evaluate the abnormal brain iron deposition in AD patients. The phase value of hippocampus is closely related to the progression of AD disease.%目的：用SWI技术观察阿尔茨海默病(AD)患者与正常对照组脑内铁含量的差异，探讨相位值与MMSE评分的相关性。方法：对31例AD患者(AD组)及10例健康老年人(NC组)进行海马及尾状核SWI扫描。比较AD组各脑区相位值与MMSE评分的相关性。结果：AD组海马及尾状核左侧及右侧均有不同程度的铁沉积。AD组均较对照组均显著增高(P＜0.05)。左右两侧海马角弧度值与 MMSE 评分均具有相关性，相关系数分别为0.43和0.45(P＜0.05)。结论：相位值可作为评价AD患者脑内铁沉积异常的敏感而有效的手段。海马相位值与AD疾病进展关系密切。