头颈部肿瘤组织中PD-L1的表达及临床意义分析

摘要

Objective To explore the expression and clinical significance of programmed cell death ligand-1( PD-L1) in head and neck tumors. Methods From January 2015 to June 2016, surgical specimens of 40 cases of head and neck malignant tumors and 20 cases of head and neck cyst tissues were prepared by embedding into paraffin blocks. The expression of PD-L1 protein was detected by immunohistochemistry SP two step method. The relationship between PD-L1 expression and clinical pathological parameters( age, sex and pathological grade and clinical stage) was investigated. Results PD-L1 was not expressed in head and neck cyst tissues, and the positive rate was 65. 0%( 26/40) in head and neck tumor tissues, significantly higher than that in head and neck cyst tissues( P<0. 05) . The expression of PD-L1 was not associated with age, sex and pathological grade( P>0. 05) , but was related to clinical stage (P<0. 05). Conclusion The expression of PD-L1 was significantly increased in head and neck malignant tumors, which could provide a reference for the immunotherapy of head and neck malignant tumors.%目的 探讨头颈部肿瘤组织中细胞程序性死亡配体-1(PD-L1)的表达情况及临床意义.方法 将2015年1月至2016年6月收治的40例头颈部恶性肿瘤组织及20例头颈部囊肿组织的手术标本经包埋制作成蜡块,采用免疫组织化学SP二步法检测以上组织中的PD-L1蛋白表达情况,分析PD-L1表达水平与临床病理参数(年龄、性别、病理分化程度和临床分期)的关系.结果 PD-L1在头颈部囊肿组织中不表达,头颈部肿瘤组织中的阳性表达率为65.0%(26/40),高于头颈部囊肿组织,差异有统计学意义(P<0.05).PD-L1表达与年龄、性别及病理分化程度无关(P>0.05),而与患者的临床分期有关(P<0.05).结论 PD-L1在头颈部恶性肿瘤组织中表达升高,可为头颈部恶性肿瘤的免疫靶向治疗提供参考.