再负荷胺碘酮治疗复发性、持续性室性心动过速的临床疗效及安全性观察

摘要

目的：评价再负荷胺碘酮治疗复发性、持续性室性心动过速的临床疗效及安全性。rn 方法：12例初次负荷量胺碘酮治疗后正在口服维持量或停药不超过3个月的复发性、持续性室性心动过速(VT)和(或)心室颤动(VF)患者，男11例，女1例，平均60.75±4.58岁。分别给予静脉并口服胺碘酮(10例)，单用口服胺碘酮800 mg/d(2例)再负荷治疗。rn 结果：12例复发性持续性VT和(或)VF均得到有效控制，未见明显副作用。再负荷胺碘酮治疗获满意疗效所需剂量约为初次负荷剂量的60%。rn 结论：再负荷胺碘酮治疗复发性、持续性VT有良好的临床疗效及安全性。%Objective:To assess the efficacy and safety of re-loading amiodarone in the treatment of recurrent sustained ventricular tachyarrhythmias.rn　　Methods:Twelve patients(11 male,1 female,mean age 60.75±4.58 years)who had orally taken maintaining dose of amiodarone or stopped taking the medicine for less than 3 months and had recurrent sustained ventricular tachyarrhythmias were treated by re-loading regimen.Ten patients were given both intravenous and orally while the other two orally alone.rn　　Results:Arrythmias in all the 12 patients were well-controled.Compared with the initial dose small dose of amiodarone(about 60% of the original dose)was required for the satisfied effect.No significant side effects were found in all the patients.rn　　Conclusion:Re-loading amiodarone for recurrent sustained ventricular tachyarrhythmias is effective and safe.