Several novel chiral sulfonamide ligands based on (1R,2S,4R,5S)-1,4-diamino-2,5-dimethylcyclohexane skele- ton have been synthesized and their application in the enantioselective addition of diethylzinc to aldehydes was in- vestigated in the presence of Ti(Oipr)4. The effect of ligands, temperature and the loading amount of ligands was studied. Under optimized conditions, enantioselective addition of diethylzinc with various aryl aldehydes and aliphatic aldehydes proceeded smoothly and afforded chiral secondary alcohols in up to 88% ee.
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