Aqueous Knoevenagel Condensation Catalyzed by Aminopropyl-functionalized MCM-41

摘要

An efficient, environmentally friendly procedure is developed for the condensation of aldehydes/ketones and activated methylene compounds by using an aminopropyl-functionalized MCM-41 catalyst in aqueous solution. Different aldehydes/ketones and activated methylene compounds gave the corresponding alkenes in 78-97% isolated yields in mild reaction conditions. In comparison with organic solution, the aqueous solution gives higher yields in the same reaction conditions. Further more, the aminopropyl-functionalized MCM-41 in aqueous system can be reused for 8 times without significant decrease of activity.