Design,synthesis and biological activity of some novel benzimidazole derivatives against Coxsackie virus B_3

Zhong Lv Zhang; Zhi Jie Sun; Fei Xue; Xian Jin Luo; Nai Yun Xiu; Li Teng; Zong Gen Peng

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Design,synthesis and biological activity of some novel benzimidazole derivatives against Coxsackie virus B_3

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A series of novel benzimidazole derivatives was synthesized and their anti-Coxsackie virus B_3(CVB_3) activity was evaluated in VERO cells.Compounds 9 and 10 exhibited better inhibitory activity than those of ribavirin(RBV) with IC_(50) values of 5.30 and 1.06μg/mL,respectively.

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《中国化学快报：英文版》 |2009年第8期|921-923|共3页
作者
Zhong Lv Zhang; Zhi Jie Sun; Fei Xue; Xian Jin Luo; Nai Yun Xiu; Li Teng; Zong Gen Peng;
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作者单位

School of Chemistry and Chemical Engineering;

Shanghai Jiaotong University;

Shanghai 200240;

PR China;

School of Life Science and Environmental Science;

Shanghai Normal University;

Shanghai 200234;

PR China;

cInstitute of Medicinal Biotechnology;

Chinese Academy of Medical Science and Peking Union Medical College;

Beijing 100050;

PR China;

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原文格式 PDF
正文语种 chi
中图分类间二氮茂（咪唑）及其衍生物;
关键词
苯并咪唑衍生物; 生物活性; 病毒; 合成; 设计; Vero细胞; 利巴韦林; 中国化学会;

机译：苯并咪唑衍生物;生物活性;病毒;合成;设计;Vero细胞;利巴韦林;中国化学会;

Design,synthesis and biological activity of some novel benzimidazole derivatives against Coxsackie virus B_3

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