First total synthesis of ocimarin

摘要

A facile approach for the first synthesis of ocimarin,naturally occurring coumarins,was developed by employing a cerium(Ⅲ) chloride heptahydrate-catalyzed Pechmann condensation of phenols andβ-keto esters in a solvent-free system as key step,by which ocimarin was achieved by three steps starting from acetylacetic ether and resorcinol with total yield 23.2%.All structures of new compounds were confirmed by IR,~1H NMR and MS.