Rhodium-catalyzed selective2+2+2cyclizations of 1,6-diynes with monoynes leading to isoindolines and isobenzofurans

摘要

A highly efficient and selective[2+2+2]cyclization of diynes and monoalkynes was catalyzed by rhodium under room temperature in water/THF mixed solvent,affording isoindolines and isobenzofurans in good to excellent yields.The center atoms (N,O) in the diynes showed a significant effect for the cyclization.