Separation of Six Pyridoncarboylxic Acid Derivatives by Micellar and Microemulsion Electrokinetic Chromatography

摘要

Micellar and microemulsion electrokinetic chromatography (MEKC & MEEKC) separation of six closely structural pyridoncarboylxic acid derivatives were studied and compared. Both anionic surfactant sodium dodecyl sulfate (SDS) and cationic surfactant hexadecyl-trimethyl ammonium bromide (CTAB) were used to form micellar and microemulsion as pseudostation phases, respectively. The effects of the separation conditions on retention time and selectivity were studied. Good resolutions were obtained in selected systems, indicating that there is markably different selectivity between SDS and CTAB systems.