Effects of Bases on the Stabilities of Nucleoside C4'Radicals

摘要

C4'-H bond dissociation enthalpies of nucleosides were predicted using theoreticalmethods to a precision of 1-2 Kcal/mol. It was found that the stability of the C4' nucleoside radicalis slightly dependent on the base. The orders of stability are dA ＜ dG ＜ dT ＜ dC fordeoxynucleosides and U ＜ G ＜ A ≈ C for nucleosides.