Reduction of Azides to Amines with New Metal /Lewis Acid Systems in H_2O or Aqueous EtOH

摘要

The azides were reduced to the corresponding amines by two new metal/Lewis acid systems in water or in aqueous EtOH in yields ranging from 80%-95%. The reaction rates were faster in water than in aqueous EtOH in most cases. All 16 azides with different functional groups were well reduced to the corresponding amines in excellent yields and reaction rates.